The little pill that could cure alcoholism

When an alcoholic doctor began experimenting with Baclofen, he made what could be the medical breakthrough of the century.

• James Medd
• The Observer

Olivier Ameisen. Photograph: Roberto Frankenberg for the Observer

"...The truth was that Ameisen, for all his successes in life, was consumed with self-loathing and shame. He was a hopeless alcoholic – hopeless in the sense that, though he seemed able to achieve anything else he put his mind to, he could not stop drinking. Despite running a thriving private practice in New York, in his late thirties he had become a binge drinker and by 1997 was regularly being admitted to hospital. He tried any treatment available: tranquillisers including Valium and Xanax, antidepressants and specific alcohol medications including Antabuse and Acamprosate. He underwent acupuncture and hypnosis, took regular exercise and practised yoga. He attended cognitive behavioural therapy and up to three meetings of Alcoholics Anonymous a day. But his drinking only got worse: "The more I drank to ease my anxiety, stave off panic and counter draining insomnia, the more I had to drink for the same effect." No longer trusting himself to treat his patients responsibly, he stopped working altogether. Finally his doctors told him he had "at best" five years of life left..."...Read complete article here...